研究方向
离子-通道工程
1. 钙通道蛋白(生物物理;调控多肽)
2. 钙离子信号(分子生理;荧光探针)
教育与工作经历
1990-1995 |
浙江大学 科仪系 |
生物医学工程/本科 |
1996-1999 |
清华大学 电机系 |
生物医学工程/硕士 |
1999-2004 |
Case Western Reserve University, BME |
生物医学工程/博士 |
2004-2010 |
Johns Hopkins University, BME and Neurosciences |
博士后 |
2010-2018 |
清华大学生物医学工程系 |
教授 |
2018-今 |
北航生物与医学工程学院 |
教授 |
主要学术兼职
中国生物医学工程学会 生物医学测量分会 委员
中国神经科学会 离子通道与受体分会 常务会员
中国生物物理学会 钙信号分会 委员
主要学术荣誉
北京航空航天大学医工百人教授 (2018)
清华大学优秀博士论文指导教师 (2018)
清华-杨森研究员奖 (2013)
科研项目
Research Grant 81971728 (PI) from NSFC, China 2020-2023
Research Grant 7191006 (PI) from BNSF, Beijing, China 2019-2021
Research Grant 21778034 (PI) from NSFC, China 2018-2021
Research Grant 31370822 (PI) from NSFC, China 2014-2017
Research Grant 7142089 (PI) from BNSF, Beijing, China 2014-2016
Research Grant 81171382 (PI) from NSFC, China 2012-2015
Research Grant 2011CB707701 (Co-PI) 973, China 2011-2015
代表性研究论文
1. Yang YX#, Geng JL#, YU Z#,et al., Li XM*, Fan YB* and Liu XD* (刘晓冬) (2022) Cytosolic peptides encoding CaV1 C-termini downregulate the calcium channel activity-neuritogenesis coupling. Communications Biology DOI: 10.1038/s42003-022-03438-1.
https://www.nature.com/articles/s42003-022-03438-1
2. Geng JL#, TangYJ#, Yu Z#, Gao YM, Li WZ, Lu YT, Wang B, Zhou HM, Li P, Liu N, Wang P, Fan YB, Yang YX*, Guo ZC*, Liu XD* (刘晓冬) (2022) Chronic Ca2+ imaging of cortical neurons with long-term expression of GCaMP-X. eLife 11:e76691 DOI: 10.7554/eLife.76691.
https://elifesciences.org/articles/76691
3. Yang YX#, Liu N#, He Y#, Liu YX, Ge L, Zou LZ, Song S, Xiong W and Liu XD* (刘晓冬) (2018) Improved calcium sensor GCaMP-X overcomes the calcium channel perturbations induced by the calmodulin in GCaMP. Nature Communications DOI: 10.1038/s41467-018-03719-6. (Faculty of 1000)
https://www.nature.com/articles/s41467-018-03719-6
4. Su Q#, Hu FZ#, Liu YX#, Ge XF, Mei CL, Yu SQ, Shen AW, Zhou Q, Yan CY, Lei JL, Zhang YQ∗, Liu XD* (刘晓冬) and Wang TL∗ (2018) Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1. Nature Communications DOI: 10.1038/s41467-018-03606-0.
https://www.nature.com/articles/s41467-018-03606-0
5. Liu N#, Yang YX#, Ge L#, Liu M, Colecraft HM and Liu XD* (刘晓冬) (2017) Cooperative and acute inhibition by multiple C-terminal motifs of L-type Ca2+ channels, eLife 6:e21989, DOI: 10.7554/eLife.21989.
http://elifesciences.org/content/6/e21989
6. Hu M#, Liu Y#, Wu J# and Liu XD* (刘晓冬) (2015) Influx-operated Ca2+ entry via PKD2-L1/PKD1-L3 channels facilitates sensory responses to polymodal transient stimuli. Cell Reports 13(4): 798-811, DOI: 10.1016/j.celrep.2015.09.041.
https://www.cell.com/cell-reports/abstract/S2211-1247(15)01066-9
7. Liu XD(刘晓冬), Yang PS, Yang W, and Yue DT* (2010) Enzyme-inhibitor-like tuning of Ca2+ channel connectivity with calmodulin. Nature 463(7283) 968-72. DOI:10.1038/nature08766. (Faculty of 1000)
https://www.nature.com/articles/nature08766 |